Preheat your oven to 350°F (175°C) and prepare a baking pan with cooking spray or parchment paper.

Cut the cheddar cheese into small cubes to ensure even melting.

In a large mixing bowl, combine the ground beef, eggs, grated Parmesan cheese, diced onion, salt, and garlic powder and mix gently until just combined.

Fold in the cubed cheddar cheese into the meat mixture.

Transfer the meat mixture to your prepared baking pan and shape it into a loaf.

Bake in the preheated oven for 50-60 minutes until the top is browned and the internal temperature reads 160°F (71°C).

Let the meatloaf rest for about 10 minutes before slicing.